Mechanisms of sustained long-term weight loss after RYGB: α-MSH is a key factor. (June 2018)

• Record Type: Journal Article
• Authors: Farias, Gisele; Netto, Bárbara Dal Molin; Boritza, Katia Cristina; Bettini, Solange Cravo; Dâmaso, Ana Raimunda; de Freitas, Alexandre Coutinho Teixeira
• Is Part Of: Neuropeptides. Volume 69(2018)
• Page Start: 60
• Page End: 65
• Publication Date: 2018-06
• Subjects: Neuropeptides -- Periodicals; Neuropeptides; Neuropeptides -- Périodiques; Neuropeptides; Electronic journals; Periodicals; 572.65
• DOI: 10.1016/j.npep.2018.04.005
• Languages: English
• ISSNs: 0143-4179

Abstract

Highlights: Leptin, α-MSH and PYY has an intrinsic action stimulating the anorexigenic pathways in a post RYGB. Anorexigenic pathways may play a prominent role in the effectiveness of the RYGB. The central melanocortin system may be a key role in sustained long-term weight loss. α-MSH contributes to weight loss by stimulate lipolysis and adipose tissue browning. Compensatory hormonal adaptation leads to increased appetite favoring weight regain.