Can Plateletcrit be a Marker for Recurrent Pregnancy Loss?. (July 2016)

• Record Type: Journal Article
• Authors: Aynıoglu, Oner; Isık, Hatice; Sahbaz, Ahmet; Harma, Mehmet I.; Isık, Metin; Kokturk, Furuzan
• Is Part Of: Clinical and applied thrombosis/hemostasis. Volume 22:Number 5(2016)
• Page Start: 447
• Page End: 452
• Publication Date: 2016-07
• Subjects: clinical thrombophilia -- recurrent abortion -- hemostasis; Hemostasis -- Periodicals; Thrombosis -- Periodicals; 616.13
• DOI: 10.1177/1076029614565882
• Languages: English
• ISSNs: 1076-0296

Abstract

Aim: To determine the utility of platelet (PLT) indices for the prediction of recurrent pregnancy loss (RPL). Methods: In all, 208 patients who experienced 2 or more first trimester spontaneous abortions and 95 controls who had no abortions were studied. The hematological markers, including plateletcrit (PCT) and neutrophil (Neu) to lymphocyte (Lym) ratio (NLR), were measured. Thrombophilia genetic tests for factor V Leiden mutation, prothrombin G202I0A mutation, and methylenetetrahydrofolate reductase C677 T and A1298C mutations were performed. Results: The PLT count, PCT, white blood cell count, red cell distribution width (RDW), Lym and Neu count, and NLR were significantly higher in patients with RPL than in controls. The RDW, PLT, and PCT values were higher in the low-risk group, whereas mean PLT volume values were lower than the high-risk group values. Conclusion: Plateletcrit is a low-cost, widely available marker for prediction of RPL in patients with a history of at least 1 abortus.