Effects of omega‐3 polyunsaturated fatty acids and aspirin, alone and combined, on canine platelet function. (9th November 2017)

• Record Type: Journal Article
• Authors: Westgarth, S.; Blois, S. L.; D. Wood, R.; Verbrugghe, A.; Ma, D. W.
• Is Part Of: Journal of small animal practice. Volume 59:Number 5(2018)
• Page Start: 272
• Page End: 280
• Publication Date: 2017-11-09
• Subjects: Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; 636.089
• DOI: 10.1111/jsap.12776
• Languages: English
• ISSNs: 0022-4510

Abstract

Abstract : Objectives: To compare haemostatic function in healthy dogs after treatment with low‐dose aspirin alone, fish oil alone or a combination of these two therapies. Materials and Methods: Double‐blinded randomised controlled clinical trial on 16 healthy client‐owned dogs. Comprehensive haemostatic testing was performed at baseline and after 7 days of therapy with low‐dose aspirin in all dogs. Following a 14‐day washout, six dogs received fish oil, and nine dogs received combination therapy of aspirin plus fish oil; haemostatic testing was performed before and at 7 and 28 days after treatment initiation. Results: Aspirin was associated with significantly decreased platelet function as measured by a collagen‐epinephrine cartridge and inhibited arachidonic acid‐induced whole‐blood platelet aggregometry. Fish oil alone did not significantly affect any haemostatic tests. The combination of aspirin plus fish oil therapy caused a significantly greater inhibition of adenosine diphosphate and collagen‐induced whole blood aggregometry compared to aspirin alone. Clinical Significance: Fish oil added to aspirin therapy appears to augment inhibition of some measures of platelet function in healthy dogs.