Women Undergoing Coronary Angiography for Myocardial Infarction or Who Present With Multivessel Disease Have a Poorer Prognosis Than Men. (July 2016)

• Record Type: Journal Article
• Authors: Gijsberts, Crystel M.; Santema, Bernadet T.; Asselbergs, Folkert W.; de Kleijn, Dominique P. V.; Voskuil, Michiel; Agostoni, Pierfrancesco; Cramer, Maarten J.; Vaartjes, Ilonca; Hoefer, Imo E.; Pasterkamp, Gerard; den Ruijter, Hester M.
• Is Part Of: Angiology. Volume 67:Number 6(2016)
• Page Start: 571
• Page End: 581
• Publication Date: 2016-07
• Subjects: epidemiology -- sex differences -- coronary angiography -- major adverse cardiovascular events; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319715604762
• Languages: English
• ISSNs: 0003-3197

Abstract

Background: Coronary artery disease affects both men and women. In this study, we examine sex-specific differences in occurrence of major adverse cardiovascular events (MACEs) after coronary angiography. Methods: We analyzed data from the coronary angiography cohort Utrecht Coronary Biobank (n = 1283 men, 480 women). Using Kaplan-Meier and multivariable Cox-regression, we tested for sex differences in MACE occurrence. Additionally, we compared mortality with an age- and sex-matched control group from the general Dutch population. Results: During a median follow-up of 2.1 years (interquartile range 1.6-2.8), MACEs occurred in 265 men and 103 women (20.7% vs 21.3%, P = .744). Women with myocardial infarction (MI) had significantly more MACE during follow-up than men (hazard ratio [HR] 1.66 for female sex, 95% confidence interval [CI] 1.10-2.50, P = .015), which was also the case for women who had multivessel disease (HR 1.41, 95% CI 1.03-1.94, P = .031). During follow-up, mortality in women presenting with MI was higher than mortality of women in the general population; men with MI did not show this disadvantage. Conclusion: MACEs occurred more often in women than in men who presented with MI or who had angiographic multivessel disease upon coronary angiography.Clinical trial registration: Clinicaltrials.gov identifier: NCT02304744. URL:https://clinicaltrials.gov/ct2/show/NCT02304744 .