On the emergent dynamics and synchronization of β-cells networks in response to space-time varying glucose stimuli. (April 2018)

• Record Type: Journal Article
• Authors: Loppini, Alessandro; Cherubini, Christian; Filippi, Simonetta
• Is Part Of: Chaos, solitons and fractals. Volume 109(2018)
• Page Start: 269
• Page End: 279
• Publication Date: 2018-04
• Subjects: β-cells -- Synchronization -- Functional networks -- Reaction–Diffusion; Chaotic behavior in systems -- Periodicals; Solitons -- Periodicals; Fractals -- Periodicals; Chaotic behavior in systems; Fractals; Solitons; Periodicals; 003.7
• DOI: 10.1016/j.chaos.2018.03.003
• Languages: English
• ISSNs: 0960-0779

Abstract

Highlights: A hybrid discrete-continuum model is used to model - cells electrophysiology coupled to glucose reaction–diffusion. Dynamic functional networks encoding correlations in cells membrane potential are used to investigate cells synchronization. Functional topology shows small-world and scale-free properties in line with experiments and arising within specific time windows. Such properties are affected by glucose diffusion. Functional features are linked to phase-locking phenomena induced by mutual coupling and intrinsic timing of the dynamics. Abstract: Recent findings based on calcium fluorescence imaging of pancreatic islets, also combined with optogenetic techniques, showed that β -cells synchronization underlie a small-world and scale-free functional organization, where specified hubs are responsible of the emergent coordination in electrical activity. Despite these features were suggested to be linked to an efficient spreading of information and calcium waves, it is still unclear from what they emerge, if they can still be observed when different dynamical variables are used to build functional networks, and how they vary upon changes in control parameters. In this work we investigate this aspect with a novel hybrid discrete-continuum mathematical model, coupling the stochastic electrical dynamics of β -cell clusters to nonlinear reaction–diffusion of glucose. By analyzing cells activity with the use of dynamical functional networks computed on the correlations between cells membrane voltage signals, we recover functional features in accordance to experimental observations. We further show that such properties are observed during specific phases of the complex electrical bursting oscillation, and are affected by glucose diffusion. These results suggest that functional properties derived from experimental calcium signals, on a time scale on the order of tens of seconds, are also recovered at a much faster time scale, i.e., on the order of hundreds of milliseconds. We finally describe how such functional features are strongly linked to synchronization patterns, in which coordinated sub-clusters of cells naturally emerge from the underlying dynamics.