Interstitial pneumonia caused by dabigatran. (2018)

• Record Type: Journal Article
• Authors: Yanagihara, Toyoshi; Yamamoto, Norio; Kotetsu, Yasuaki; Hamada, Naoki; Harada, Eiji; Suzuki, Kunihiro; Ijichi, Kayo; Oda, Yoshinao; Nakanishi, Yoichi
• Is Part Of: Respiratory medicine case reports. Volume 23(2018)
• Page Start: 10
• Page End: 12
• Publication Date: 2018
• Subjects: Dabigatran -- Interstitial pneumonia -- Drug-induced lung injury; OP organizing pneumonia -- HRCT high-resolution computed tomography -- NSIP nonspecific interstitial pneumonia -- BALF Bronchoalveolar lavage fluid; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2017.10.009
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: We describe the case of a 73-year-old man who experienced dry cough and exertional dyspnea after dabigatran administration. Chest radiographs revealed the development of bilateral consolidative and ground glass opacity, and transbronchial lung biopsy showed organized materials in the alveolar spaces with moderate inflammatory infiltrate and focal fibrosis. Lung opacity gradually disappeared after discontinuing dabigatran. To date, there has been only one report regarding dabigatran-induced lung injury, except for alveolar hemorrhage and eosinophilic pneumonia. Therefore, we should consider that any drug can cause various types of lung injuries.