Erythropoietin Dampens Injury-Induced Microglial Motility. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Mitkovski, Miso; Dahm, Liane; Heinrich, Ralf; Monnheimer, Mathieu; Gerhart, Simone; Stegmüller, Judith; Hanisch, Uwe-Karsten; Nave, Klaus-Armin; Ehrenreich, Hannelore
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 35:Issue 8(2015)
• Page Start: 1233
• Page End: 1236
• Publication Date: 2015-08
• Subjects: ATP -- brain injury -- migration -- process protrusion -- Rac1; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1038/jcbfm.2015.100
• Languages: English
• ISSNs: 0271-678X

Abstract

Traumatic brain injury causes progressive brain atrophy and cognitive decline. Surprisingly, an early treatment with erythropoietin (EPO) prevents these consequences of secondary neurodegeneration, but the mechanisms have remained obscure. Here we show by advanced imaging and innovative analytical tools that recombinant human EPO, a clinically established and neuroprotective growth factor, dampens microglial activity, as visualized also in vivo by a strongly attenuated injury-induced cellular motility.