Biology of Cerebral Arteriovenous Malformations with a Focus on Inflammation. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Mouchtouris, Nikolaos; Jabbour, Pascal M; Starke, Robert M; Hasan, David M; Zanaty, Mario; Theofanis, Thana; Ding, Dale; Tjoumakaris, Stavropoula I; Dumont, Aaron S; Ghobrial, George M; Kung, David; Rosenwasser, Robert H; Chalouhi, Nohra
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 35:Issue 2(2015)
• Page Start: 167
• Page End: 175
• Publication Date: 2015-02
• Subjects: angiogenesis -- arteriovenous malformations -- AVM -- endothelial cell -- inflammation -- intracerebral hemorrhage; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1038/jcbfm.2014.179
• Languages: English
• ISSNs: 0271-678X

Abstract

Cerebral arteriovenous malformations (AVMs) entail a significant risk of intracerebral hemorrhage owing to the direct shunting of arterial blood into the venous vasculature without the dissipation of the arterial blood pressure. The mechanisms involved in the growth, progression and rupture of AVMs are not clearly understood, but a number of studies point to inflammation as a major contributor to their pathogenesis. The upregulation of proinflammatory cytokines induces the overexpression of cell adhesion molecules in AVM endothelial cells, resulting in enhanced recruitment of leukocytes. The increased leukocyte-derived release of metalloproteinase-9 is known to damage AVM walls and lead to rupture. Inflammation is also involved in altering the AVM angioarchitecture via the upregulation of angiogenic factors that affect endothelial cell proliferation, migration and apoptosis. The effects of inflammation on AVM pathogenesis are potentiated by certain single-nucleotide polymorphisms in the genes of proinflammatory cytokines, increasing their protein levels in the AVM tissue. Furthermore, studies on metalloproteinase-9 inhibitors and on the involvement of Notch signaling in AVMs provide promising data for a potential basis for pharmacological treatment of AVMs. Potential therapeutic targets and areas requiring further investigation are highlighted.