CD28 Superagonist-Mediated Boost of Regulatory T Cells Increases Thrombo-Inflammation and Ischemic Neurodegeneration during the Acute Phase of Experimental Stroke. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Schuhmann, Michael K; Kraft, Peter; Stoll, Guido; Lorenz, Kristina; Meuth, Sven G; Wiendl, Heinz; Nieswandt, Bernhard; Sparwasser, Tim; Beyersdorf, Niklas; Kerkau, Thomas; Kleinschnitz, Christoph
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 35:Issue 1(2015)
• Page Start: 6
• Page End: 10
• Publication Date: 2015-01
• Subjects: brain ischemia -- inflammation -- microcirculation -- T cells -- thrombosis; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1038/jcbfm.2014.175
• Languages: English
• ISSNs: 0271-678X

Abstract

While the detrimental role of non-regulatory T cells in ischemic stroke is meanwhile unequivocally recognized, there are controversies about the properties of regulatory T cells (Treg ). The aim of this study was to elucidate the role of Treg by applying superagonistic anti-CD28 antibody expansion of Treg . Stroke outcome, thrombus formation, and brain-infiltrating cells were determined on day 1 after transient middle cerebral artery occlusion. Antibody-mediated expansion of Treg enhanced stroke size and worsened functional outcome. Mechanistically, Treg increased thrombus formation in the cerebral microvasculature. These findings confirm that Treg promote thrombo-inflammatory lesion growth during the acute stage of ischemic stroke.