A Method for Reducing the Effects of Motion Contamination in Arterial Spin Labeling Magnetic Resonance Imaging. Issue 10 (October 2015)

• Record Type: Journal Article
• Authors: Tanenbaum, Aaron B; Snyder, Abraham Z; Brier, Matthew R; Ances, Beau M
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 35:Issue 10(2015)
• Page Start: 1697
• Page End: 1702
• Publication Date: 2015-10
• Subjects: arterial spin labeling -- ASL -- cerebral blood flow measurement -- perfusion-weighted MRI; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1038/jcbfm.2015.124
• Languages: English
• ISSNs: 0271-678X

Abstract

Arterial spin labeling (ASL) is a noninvasive method to measure cerebral blood flow (CBF). Arterial spin labeling is susceptible to artifact generated by head motion; this artifact is propagated through the subtraction procedure required to calculate CBF. We introduce a novel strategy for mitigating this artifact based on weighting tag/control volumes according to a noise estimate. We evaluated this strategy (DVARS weighting) in application to both pulsed ASL (PASL) and pseudo-continuous ASL (pCASL) in a cohort of normal adults (N = 57). Application of DVARS weighting significantly improved test-retest repeatability as assessed by the intra-class correlation coefficient. Before the application of DVARS weighting, mean gray matter intra-class correlation (ICC) between subsequent ASL runs was 0.48 and 0.51 in PASL and pCASL, respectively. With weighting, ICC was significantly improved to 0.63 and 0.58.