Spindle Cell Epithelioma of the Vagina: Report of Two Cases, Literature Review, and New Immunohistochemical Markers. (December 2015)

• Record Type: Journal Article
• Authors: Berdugo, Jérémie; Gauthier, Philippe; Provencher, Diane; Matte, Claire; Piché, Jean; Rahimi, Kurosh
• Is Part Of: International journal of surgical pathology. Volume 23:Number 8(2015)
• Page Start: 677
• Page End: 681
• Publication Date: 2015-12
• Subjects: spindle cell epithelioma -- mixed tumor -- vagina; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896915587920
• Languages: English
• ISSNs: 1066-8969

Abstract

Spindle cell epitheliomas of the vagina are rare benign tumors of uncertain histogenesis. It has been hypothesized that they originate from a pluripotent cell population. Here, we report 2 cases of spindle cell epitheliomas of the vagina. Both patients presented with a painless vaginal nodule. The resected lesions were solid, well circumscribed, and composed of a proliferation of epithelioid or epithelial cells admixed with spindle cells without atypia. The 2 cellular populations expressed epithelial and mesenchymal markers. Based on these morphologic and immunohistochemical findings, a diagnosis of spindle cell epithelioma was rendered in both cases. Furthermore, we describe for the first time the expression of WT-1 (Wilms' tumor protein 1) and calretinin in addition to the previously defined immunohistochemical profile.