Physiological functions of vitamin D: what we have learned from global and conditional VDR knockout mouse studies. (June 2015)

• Record Type: Journal Article
• Authors: Suda, Tatsuo; Masuyama, Ritsuko; Bouillon, Roger; Carmeliet, Geert
• Is Part Of: Current opinion in pharmacology. Volume 22(2015)
• Page Start: 87
• Page End: 99
• Publication Date: 2015-06
• Subjects: Pharmacology -- Periodicals; Pharmaceutical Preparations -- Periodicals; Drug Therapy -- Periodicals; Biopharmaceutics -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Periodicals; 615.105
• DOI: 10.1016/j.coph.2015.04.001
• Languages: English
• ISSNs: 1471-4892

Abstract

Highlights: The physiological role of vitamin D depends on calcium supply and calcium balance. When the calcium balance is normal, the major target of vitamin D is intestine. Vitamin D stimulates mainly active intestinal calcium transport mechanism. During a negative calcium balance, bone effects of vitamin D become dominant. The role of vitamin D in maintaining normocalcemia has priority over skeletal integrity. Abstract : The physiological role of vitamin D depends on calcium supply and calcium balance. When the calcium balance is normal, the major target of vitamin D is intestine. Vitamin D stimulates mainly active intestinal calcium transport mechanism. During a negative calcium balance, bone effects of vitamin D become dominant. Thus, the role of vitamin D in maintaining normocalcemia appears to have priority over skeletal integrity in these situations.