Effects of Lycium barbarum on bacterial translocation in thioacetamide-induced liver injury in rats. (December 2015)

• Record Type: Journal Article
• Authors: Bilgic, Y; Harputluoglu, MMM; Kutlu, O; Demirel, U; Gul, M; Otlu, B; Temel, I; Gursoy, S; Dertli, R; Selcuk, EB; Yilmaz, I; Kilis, T
• Is Part Of: European journal of inflammation. Volume 13:Number 3(2015)
• Page Start: 154
• Page End: 163
• Publication Date: 2015-12
• Subjects: bacterial translocation -- liver injury -- Lycium barbarum -- thioacetamide; Inflammation -- Periodicals; Anti-Inflammatory Agents -- therapeutic use -- Periodicals; Immunotherapy -- Periodicals; Inflammation -- Periodicals; Anti-inflammatory agents -- Periodicals; Immunotherapy -- Periodicals; Anti-inflammatory agents; Immunotherapy; Inflammation; Periodicals; 616.0473
• DOI: 10.1177/1721727X15618413
• Languages: English
• ISSNs: 1721-727X

Abstract

Background and study aim: The aim of the present study was to investigate the effects of Lycium barbarum (LB) on bacterial translocation (BT) frequency in thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Group 1 was the control. In group 2 (TAA), rats received TAA daily for 3 days. In group 3 (TAA+LB), Lycium barbarum was administered orally 25 mg/kg for 21 days prior to the first TAA injection. In group 4 (LB), rats received only Lycium barbarum . Results: In our study, Lycium barbarum treatment did not attenuate liver damage. Lycium barbarum treatment decreased ileal E. coli counts and intestinal damage but it did not alter BT frequency. Conclusions: In conclusion, the effects of Lycium barbarum on BT may be related to ongoing severe liver damage in this model.