Antioxidant profile of constituents isolated from Polygonatumverticillatum rhizomes. (January 2016)

• Record Type: Journal Article
• Authors: Khan, Haroon; Saeed, Muhammad; Muhammad, Naveed; Rauf, Abdur; Khan, Amir Zada; Ullah, Rooh
• Is Part Of: Toxicology and industrial health. Volume 32:Number 1(2016)
• Page Start: 138
• Page End: 142
• Publication Date: 2016-01
• Subjects: Polygonatumverticillatum -- rhizomes -- diosgenin -- santonin -- DPPH; Toxicology, Experimental -- Periodicals; Industrial toxicology -- Periodicals; 615.9
• DOI: 10.1177/0748233713498454
• Languages: English
• ISSNs: 0748-2337

Abstract

The purpose of the current study was to estimate the antioxidant profile of two compounds, diosgenin and santonin, isolated from Polygonatum verticillatum rhizomes. Stable free radical, 2, 2-diphenyl-1-picrylhydrazyl and reducing power assays were employed for this purpose. The results showed profound free radical scavenging effect of both diosgenin and santonin in a concentration-dependent manner. The calculated half maximal inhibitory concentration (IC50 ) values for both diosgenin and santonin was 65.80 and 50.03 μg/ml, respectively. Similarly, in reducing power assay, diosgenin and santonin exhibited marked quenching effect. The corresponding IC50 values for both the compounds were 62.10 and 46.40 μg/ml, respectively. In conclusion, both the isolated compounds have strong antioxidant potential, which is consistent with the results of the extracts of the plant.