Cerebrospinal fluid amounts of HLA-G in dimeric form are strongly associated to patients with MRI inactive multiple sclerosis. (February 2016)

• Record Type: Journal Article
• Authors: Fainardi, Enrico; Bortolotti, Daria; Bolzani, Silvia; Castellazzi, Massimiliano; Tamborino, Carmine; Roversi, Gloria; Baldi, Eleonora; Caniatti, Maria Luisa; Casetta, Ilaria; Gentili, Valentina; Granieri, Enrico; Rizzo, Roberta
• Other Names: Granieri E non-byline-author.; Castellazzi M non-byline-author.; Casetta I non-byline-author.; Tola MR non-byline-author.; Fainardi E non-byline-author.; Dallocchio F non-byline-author.; Bellini T non-byline-author.; Rizzo R non-byline-author.; Rotola A non-byline-author.; Di Luca D non-byline-author.; Seraceni S non-byline-author.; Contini C non-byline-author.; Sabbioni S non-byline-author.; Negrini M non-byline-author.; Tognon M non-byline-author.; Antonelli T non-byline-author.; Groppo E non-byline-author.; Gentile M non-byline-author.; Baldi E non-byline-author.; Caniatti ML non-byline-author.; Ceruti S non-byline-author.; Manfrinato MR non-byline-author.; Trentini A non-byline-author.; Bortolotti D non-byline-author.; Miotto E non-byline-author.; Ferracin M non-byline-author.; Mazzoni E non-byline-author.; Pietrobon S non-byline-author.; Masini I non-byline-author.; Rotondo JC non-byline-author.; Martini F non-byline-author.; Baruzzi A non-byline-author.; Roberto D'Alessandro R non-byline-author.; Michelucci R non-byline-author.; Salvi F non-byline-author.; Stecchi S non-byline-author.; Scandellari C non-byline-author.; Terzano G non-byline-author.; Granella F non-byline-author.; Nichelli P non-byline-author.; Sola P non-byline-author.; Ferraro D non-byline-author.; Vitetta F non-byline-author.; Simone AM non-byline-author.; Bedin R non-byline-author.; Marcello N non-byline-author.; Motti L non-byline-author.; Montepietra S non-byline-author.; Guidetti D non-byline-author.; Immovilli P non-byline-author.; Montanari E non-byline-author.; Pesci I non-byline-author.; Guareschi A non-byline-author.; Greco G non-byline-author.; Santangelo M non-byline-author.; Mauro AM non-byline-author.; Malagù S non-byline-author.; Rasi F non-byline-author.; Spadoni M non-byline-author.; Galeotti M non-byline-author.; Fiorani L non-byline-author.; Neri W non-byline-author.; Ravasio A non-byline-author.; Pasquinelli M non-byline-author.; Gutman S non-byline-author.; Monaldini C non-byline-author.;
• Is Part Of: Multiple sclerosis. Volume 22:Number 2(2016)
• Page Start: 245
• Page End: 249
• Publication Date: 2016-02
• Subjects: Multiple Sclerosis -- HLA-G -- dimeric form -- CSF levels -- MRI activity; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458515590647
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: The relevance of human leukocyte antigen (HLA)-G in dimeric form in multiple sclerosis (MS) is still unknown. Objective: To investigate the contribution of cerebrospinal fluid (CSF) HLA-G dimers in MS pathogenesis. Methods: CSF amounts of 78-kDa HLA-G dimers were measured by western blot analysis in 80 MS relapsing–remitting MS (RRMS) patients and in 81 inflammatory and 70 non-inflammatory controls. Results: CSF amounts of 78kDa HLA-G dimers were more frequent in RRMS than in inflammatory ( p <0.01) and non-inflammatory controls ( p <0.001) and in magnetic resonance imaging (MRI) inactive than in MRI active RRMS ( p <0.00001). Conclusion: Our findings suggest that HLA-G dimers may be implicated in termination of inflammatory response occurring in MS.