Essential oil extraction, chemical analysis and anti-Candida activity of Foeniculum vulgare Miller – new approaches. Issue 11 (3rd June 2018)

• Record Type: Journal Article
• Authors: Garzoli, Stefania; Božović, Mijat; Baldisserotto, Anna; Sabatino, Manuela; Cesa, Stefania; Pepi, Federico; Vicentini, Chiara Beatrice; Manfredini, Stefano; Ragno, Rino
• Is Part Of: Natural product research. Volume 32:Issue 11(2018)
• Page Start: 1254
• Page End: 1259
• Publication Date: 2018-06-03
• Subjects: Foeniculum vulgare Miller -- 24-h steam distillation -- GC/MS -- essential oils -- anti-Candida activity -- estragole, o-cymene; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1340291
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A comprehensive study on essential oil samples of Foeniculum vulgare Miller from Tarquinia (Italy) is reported. A 24-h systematic steam distillation was performed on different harvested samples applying different extraction times. The GC-MS analysis of the residue outcome showed o -cymene, α -phellandrene, α -pinene and estragole as the major constituents. The predominance and continued presence of o -cymene makes this fennel oil a rather unique chemotype. An evident correlation between the antifungal activity and phenological stage is demonstrated. The most active fractions were particularly rich in estragole, as well as a significant amount of fenchone that possibly exerts some additive effect in the expression of overall antifungal potency. Pre-fruiting material produced oil particularly rich in o -cymene. With reference to the duration of the extraction, the maximum amount of oil was released within the first 3 h, whereas the reproductive phase material needed at least 6 h for the extraction. Abstract :