Natural history of fetal isolated ventriculomegaly: Comparison between pre- and post-natal imaging. (3rd July 2018)

• Record Type: Journal Article
• Authors: Perlman, Sharon; Bar-Yosef, Omer; Jacobson, Jeffrey-Michael; Gilboa, Yinon; Derazne, Estela; Achiron, Reuven; Katorza, Eldad
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 31:Number 13(2018)
• Page Start: 1762
• Page End: 1767
• Publication Date: 2018-07-03
• Subjects: Isolated ventriculomegaly -- post-natal -- pre-natal -- MRI -- ultrasound; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2017.1326903
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Purpose: The aim of our study was to assess the agreement between pre- and post-natal measurements in prenatal isolated ventriculomegaly. Methods: Ninety-two women were referred for lateral ventricular abnormality and followed prospectively. Cases with at least one dilated lateral ventricle ≥10 mm and a normal work up (serological tests, detailed anatomical scan, fetal brain MR imaging, genetic counseling, and amniocentesis) were considered idiopathic ventriculomegaly and comprised the study group for post-natal follow up. Prenatal measurements were performed by ultrasound and MR imaging. Post-natal measurements were performed by cranial sonography at age of 1–3 months. Measurements were performed in the customary plane for each modality. Paired Student's t test was used to assess the mean difference between pre- and postnatal measurements. Results: Forty three cases comprised the study group for post-natal measurements. A statistically significant decrease in ventricular width ( p < .001) was observed between pre- and post-natal measurements. On clinical follow up for 24 months, all cases were normal except three who demonstrated very mild neurological deficits. Conclusions: Our study indicates statistically significant regression of prenatal isolated ventriculomegaly in the post-natal period.