Development and characterization of chitosan/hyaluronan film for transdermal delivery of thiocolchicoside. (5th October 2015)

• Record Type: Journal Article
• Authors: Bigucci, Federica; Abruzzo, Angela; Saladini, Bruno; Gallucci, Maria Caterina; Cerchiara, Teresa; Luppi, Barbara
• Is Part Of: Carbohydrate polymers. Volume 130(2015)
• Page Start: 32
• Page End: 40
• Publication Date: 2015-10-05
• Subjects: Chitosan (PubMed CID: 71853) -- Sodium hyaluronate (PubMed CID: 3084049) -- Thiocolchicoside (PubMed CID 72067); Chitosan/hyaluronan complexes -- Hydrogels -- Polymeric films -- Transdermal delivery -- Thiocolchicoside; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.04.067
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Films based on different weight ratios of chitosan and hyaluronate were prepared. Water-uptake ability changed in relation to polymeric composition of film. The lower the drug diffusion through the film, the lower the permeation through the skin. Abstract: The objective of this study was the development of chitosan/hyaluronan transdermal films to improve bioavailability of thiocolchicoside. This approach offers the possibility to elude the first-pass metabolism and at the same time it is able to provide a predictable and extended duration of activity. Films were prepared by casting and drying of aqueous solutions containing different weight ratios of chitosan and hyaluronan and characterized for their physico-chemical and functional properties. In accordance with polymeric composition of films and, therefore, with the amount of the net charge after the complexation, films containing the same weight ratio of chitosan and hyaluronan showed lower water uptake ability with respect to films containing only one polymeric species or an excess of chitosan or hyaluronan. Moreover, the lower the hydration of the polymeric network, the lower is the drug diffusion through the films and its permeation through the skin. This study clearly confirmed that the selection of a suitable polymeric weight ratio and appropriate preparative conditions allows the modulation of film functional properties, suggesting that these formulations could be used as a novel technological platform for transdermal drug delivery.