The Degree of Autonomic Modulation Is Associated With the Severity of Microvascular Complications in Patients With Type 1 Diabetes. (14th January 2015)

• Record Type: Journal Article
• Authors: Fleischer, Jesper; Cichosz, Simon Lebech; Jakobsen, Poul Erik; Yderstraede, Knud; Gulichsen, Elisabeth; Nygaard, Hans; Eldrup, Ebbe; Lervang, Hans Henrik; Tarnow, Lise; Ejskjaer, Niels
• Is Part Of: Journal of diabetes science and technology. Volume 9:Number 3(2015:May)
• Page Start: 681
• Page End: 686
• Publication Date: 2015-01-14
• Subjects: microvascular complications -- type 1 diabetes -- heart rate variability (HRV); Diabetes -- Periodicals; Medical technology -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1177/1932296814567226
• Languages: English
• ISSNs: 1932-2968

Abstract

Objective: The objective of this study was to elucidate whether the degree of autonomic modulation is associated with the degree of microvascular complications in patients with type 1 diabetes.Methods: A total of 290 type 1 individuals with diabetes were randomly recruited during normal visits to outpatient clinics at 4 Danish hospitals. The degree of autonomic modulations was quantified by measuring heart rate variability (HRV) during passive spectral analysis and active tests (valsalva ratio [VT], response to standing [RT], and deep breathing [E:I]). To describe possible associations between severity of microvascular complications and measures of autonomic modulation, multivariate analysis was performed.Results: After adjusting for diabetes duration, sex, age, pulse pressure, heart rate, and smoking, autonomic dysfunction remained significantly correlated with severity of retinopathy, nephropathy, and peripheral neuropathy in individuals with type 1 diabetes patients.Conclusions: Autonomic dysfunction is present in early stages of retinopathy, nephropathy, and peripheral neuropathy in patients with type 1 diabetes.