Sodium sulfide in methanol: a two-in-one reagent for deprotection of silyl and formation of propargyl sulfide. Issue 29 (15th July 2015)

• Record Type: Journal Article
• Authors: Hatial, Ishita; Mukherjee, Raja; Senapati, Kalyan; Basak, Amit
• Is Part Of: Tetrahedron letters. Volume 56:Issue 29(2015)
• Page Start: 4275
• Page End: 4279
• Publication Date: 2015-07-15
• Subjects: Sodium sulfide -- Deprotection -- Sulfide -- Desilylation -- Chemoselective; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.04.104
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A new reagent Na2 S/MeOH for silyl deprotection has been developed. The reagent has several advantages which include deprotection of C-TMS, O-TMS, O-TBS, and O-TBDPS, selective removal of C-TMS and O-TMS in the presence of O-TBS and simultaneous desilylation and sulfide formation in one pot.