Diastereoselective synthesis of the C29–C41 fragment of karlotoxin 2. Issue 29 (15th July 2015)

• Record Type: Journal Article
• Authors: Reddy, D. Srinivas; Gaddam, Janardhan; Devunuri, Nagaraju; Mohapatra, Debendra K.
• Is Part Of: Tetrahedron letters. Volume 56:Issue 29(2015)
• Page Start: 4299
• Page End: 4301
• Publication Date: 2015-07-15
• Subjects: Regioselective epoxide opening -- Domino isomerization followed by C–O and C–C bond -- Formation reaction -- Sharpless asymmetric dihydroxylation -- Chelation-controlled Grignard reaction; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.05.051
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A highly diastereoselective synthesis of the C29–C41 fragment of karlotoxin 2 (KmTx2) is described by employing regio-selective epoxide opening, our own developed domino isomerization followed by C–O and C–C bond formation reaction and chelation-controlled Grignard reaction as key steps. The synthesis involves installation of seven stereocenters present in the C29–C41 fragment of karlotoxin 2.