A comparison between plasmapheresis and intravenous immunoglobulin in children with Guillain–Barré syndrome in Upper Egypt. (January 2016)

• Record Type: Journal Article
• Authors: Saad, Khaled; Mohamad, Ismail L.; Abd El-Hamed, Mohamed A.; Tawfeek, Mostafa S K; Ahmed, Ahmed E.; Abdel Baseer, Khaled A.; El-Shemy, Ahmed S.; El-Houfey, Amira A.; Tamer, Diaa M.
• Is Part Of: Therapeutic advances in neurological disorders. Volume 9:Number 1(2016:Jan.)
• Page Start: 3
• Page End: 8
• Publication Date: 2016-01
• Subjects: children -- Guillain–Barré Syndrome -- intravenous immunoglobulin -- plasmapheresis -- outcome; Nervous system -- Diseases -- Periodicals; Nervous system -- Degeneration -- Periodicals; Nervous system -- Diseases -- Treatment -- Periodicals; Nervous System Diseases -- therapy -- Periodicals; Neurodegenerative Diseases -- Periodicals; Système nerveux -- Maladies -- Périodiques; Système nerveux -- Dégénérescence -- Périodiques; Système nerveux; Système nerveux -- Maladies -- Traitement -- Périodiques; 616.805
• DOI: 10.1177/1756285615610471
• Languages: English
• ISSNs: 1756-2856

Abstract

Objective: The aim of our study is to assess the clinico-electrophysiological profile of children with Guillain–Barré syndrome (GBS) in Upper Egypt and to compare the efficacy of plasmapheresis versus other treatment modalities. Patients and methods: This was a retrospective study of children from January 2010 to October 2014 diagnosed as GBS. It included 62 cases. Results: Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) was the most prevalent type of GBS in our locality. As regards the treatment, 32 cases received plasmapheresis while 30 patients received intravenous immunoglobulin. We found a significant decrease in the duration of hospitalization and a significant increase in the number of children with complete recovery in cases treated with plasmapheresis. Conclusion: GBS is not uncommon in children of Upper Egypt, with AIDP the most prevalent type. Plasmapheresis is the best treatment modalities for GBS as it reduces the duration of hospital stay and hastens the recovery of those children.