Demonstration of the bactericidal effects of the boron neutron capture reaction. (July 2018)

• Record Type: Journal Article
• Authors: Maitz, Charles A.; Brockman, John D.; Yang, Ming; Zhang, Shuping; Stannard, James; Volgas, David; Gahl, John M.
• Is Part Of: Applied radiation and isotopes. Volume 137(2018:Jul.)
• Page Start: 190
• Page End: 193
• Publication Date: 2018-07
• Subjects: Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2018.04.011
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: This pilot study represents a paradigm shift, using BNCT for the treatment of bacterial overgrowth on surgically implanted medical devices. In this study, titanium diboride disks were inoculated with S. aureus and irradiated in a thermal neutron beam. After a delivery of 2.6 × 10 12 n/cm 2 the surviving fraction of S. aureus on an irradiated disk was 3.1 × 10 −5 when compared with non-irradiated controls. This pilot study demonstrates proof of principle of boron neutron capture therapy for infection control (BNCIC). Highlights: Bactericidal effects of boron neutron capture reaction demonstrated on S. aureus . Bacteria irradiated on titanium diboride disks in thermal neutron beam. 2.6 × 10 12 n/cm 2 delivered resulted in a surviving fraction of 3.1 × 10 −5 . Dose modeling estimated a dose of 14 kGy delivered in a 60 min irradiation.