Associations between the functional CD40 rs4810485 G/T polymorphism and susceptibility to rheumatoid arthritis and systemic lupus erythematosus: a meta-analysis. (October 2015)

• Record Type: Journal Article
• Authors: Lee, Y H; Bae, S-C; Choi, S J; Ji, J D; Song, G G
• Is Part Of: Lupus. Volume 24:Number 11(2015)
• Page Start: 1177
• Page End: 1183
• Publication Date: 2015-10
• Subjects: Rheumatoid arthritis -- systemic lupus erythematosus -- CD40 -- polymorphism. meta-analysis; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/0961203315583543
• Languages: English
• ISSNs: 0961-2033

Abstract

Objective: The aim of this study was to determine whether the functional CD40 rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) or with susceptibility to systemic lupus erythematosus (SLE). Methods: A series of meta-analyses were conducted to test for association between the CD40 rs4810485 G/T polymorphism and RA or SLE. Results: A total of 21 comparisons involving 15, 095 patients and 27, 050 controls for RA, and 1353 patients and 2342 controls for SLE were considered. Meta-analysis showed a significant association between the CD40 rs4810485 T allele and RA in all subjects (odds ratio (OR) 0.890, 95% confidence interval (CI) 0.846–0.936, p = 5.5 × 10 −7 ). After stratification by ethnicity, the CD40 T allele was found to be significantly associated with RA in Europeans (OR 0.879, 95% CI 0.848–0.901, p = 3.0 × 10 −9 ). A similar pattern of association was observed between the CD40 T allele and RA when the analysis was performed using the recessive, dominant, and additive models. Meta-analysis also showed a significant association between the CD40 polymorphism and SLE in Europeans (OR for the T allele 0.715, 95% CI 0.641–0.832, p = 1.4 × 10 −6 ). Conclusions: Our meta-analyses confirm that the CD40 rs4810485 G/T polymorphism is associated with susceptibility to RA and SLE in Europeans.