The emerging role of nanomaterials in immunological sensing — a brief review. (June 2018)

• Record Type: Journal Article
• Authors: Corrie, Simon R.; Plebanski, Magdalena
• Is Part Of: Molecular immunology. Volume 98(2018:Jun.)
• Page Start: 28
• Page End: 35
• Publication Date: 2018-06
• Subjects: Nanomaterials -- Sensitivity -- Cell array -- Plasmonic -- Cytokine; Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2017.12.017
• Languages: English
• ISSNs: 0161-5890

Abstract

Highlights: Nanomaterials are increasingly being incorporated into immunological assays and sensors. Sensitivity of assays for detection of low abundance proteins have been improved by orders of magnitude based on unique properties of nanomaterials. Continuous and real-time monitoring of multiplexed cytokine secretion from arrays of individual cells is now possible. Key challenge is the real-time and continuous monitoring of cytokines and other immunological biomarkers in vivo . Abstract: Nanomaterials are beginning to play an important role in the next generation of immunological assays and biosensors, with potential impacts both in research and clinical practice. In this brief review, we highlight two areas in which nanomaterials are already making new and important contributions in the past 5–10 years: firstly, in the improvement of assay and biosensor sensitivity for detection of low abundance proteins of immunological significance, and secondly, in the real-time and continuous monitoring of protein secretion from arrays of individual cells. We finish by challenging the immunology/sensing communities to work together to develop nanomaterials that can provide real-time, continuous, and sensitive molecular readouts in vivo, a lofty goal that will require significant collaborative effort.