Topographical Distribution of Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex. (April 2016)

• Record Type: Journal Article
• Authors: Ellingson, Benjamin M.; Hirata, Yoko; Yogi, Akira; Karavaeva, Elena; Leu, Kevin; Woodworth, Davis C.; Harris, Robert J.; Enzmann, Dieter R.; Wu, Joyce Y.; Mathern, Gary W.; Salamon, Noriko
• Is Part Of: Journal of child neurology. Volume 31:Number 5(2016:May)
• Page Start: 636
• Page End: 645
• Publication Date: 2016-04
• Subjects: tuberous sclerosis complex -- tuberous sclerosis complex -- population maps -- analysis of differential involvement -- seizures -- epilepsy -- topographic mapping; Nervous system -- Diseases -- Periodicals; 618.928
• DOI: 10.1177/0883073815609151
• Languages: English
• ISSNs: 0883-0738

Abstract

Tuberous sclerosis complex is a multisystem genetic syndrome often affecting the central nervous system. The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the inferior parietal lobe and within the central sulcus region in children younger than 1 or between 1 and 3 years old, respectively. Results imply seizure activity in tuberous sclerosis complex patients can be associated with the location of cortical tubers.