Biosensing: A General Strategy of Aerolysin Nanopore Detection for Oligonucleotides with the Secondary Structure (Small 18/2018). Issue 18 (3rd May 2018)

• Record Type: Journal Article
• Authors: Liao, Dong‐Fang; Cao, Chan; Ying, Yi‐Lun; Long, Yi‐Tao
• Is Part Of: Small. Volume 14:Issue 18(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-05-03
• Subjects: aerolysin -- nanopores -- oligonucleotides -- single‐molecule detection; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201870080
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Aerolysin‐based direct analysis of oligonucleotides with secondary structure (e.g., G‐quadruplex) remains a challenge. In article number1704520, Yi‐Lun Ying, Yi‐Tao Long, and co‐workers present a strategy employing an aerolysin nanopore to analyze structured oligonucleotides that are extended to 30 bases in length by a cation‐regulation mechanism. This method can in principle be applied to genetic and epigenetic biosensing, making it practical for diagnostics.