Bismuth Ferrite‐Based Nanoplatform Design: An Ablation Mechanism Study of Solid Tumor and NIR‐Triggered Photothermal/Photodynamic Combination Cancer Therapy. (2nd March 2018)

• Record Type: Journal Article
• Authors: Yang, Chunyu; Chen, Yaodong; Guo, Wei; Gao, Yan; Song, Chuanqi; Zhang, Qun; Zheng, Nannan; Han, Xiaojun; Guo, Chongshen
• Is Part Of: Advanced functional materials. Volume 28:Number 18(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-03-02
• Subjects: B‐mode ultrasonography -- in vivo tumor ablation mechanism -- magnetic resonance imaging -- photodynamic therapy -- photothermal therapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201706827
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Although nanomaterial‐mediated phototherapy, in particular photothermal therapy (PTT) and photodynamic therapy (PDT), is extensively investigated in recent years, the ablation mechanism, evolution, and rehabilitation process of in vivo solid tumor after phototherapy are rarely explored yet and remain a terra incognita. Herein, a kind of bismuth ferrite nanoparticles (abbreviated as BFO NPs) are strategically designed and synthesized with a desirable size and bioactivity as a brand‐new phototherapeutic agent for the phototherapy, which are of strong near infrared (NIR) absorbance, excellent biocompatibility, and outstanding photophysical activity for the hyperthemia and reactive oxygen species generation. Resultantly, BFO NPs can realize simultaneous PTT/PDT synergistic therapy outcome against cancer cells and solid tumor under NIR laser irradiation. Meanwhile, for the first time, more attentions are paid to demonstrate ablation mechanism and evolution process of in vivo solid tumor after phototherapy by B‐mode ultrasonography/magnetic resonance imaging as well as histopathological analysis, all of which verify a series of physiological processes, being in order of necrosis of parenchymal cells, in situ tissue disintegration, liquefaction, and finally encapsulation process. Abstract : A brand‐new photoactive material of bismuth ferrite nanoparticle, which can behave as photothermal agents and photosensitizer simultaneously and thus realize photothermal therapy/photodynamic therapy synergistic treatment, is presented. Meanwhile, ablation mechanism and disappearance process of solid tumor, which undergoes necrosis of parenchymal cells, in situ tissue disintegration, liquefaction, and encapsulation process, are demonstrated.