Sugar sensing by ChREBP/Mondo-Mlx — new insight into downstream regulatory networks and integration of nutrient-derived signals. (April 2018)

• Record Type: Journal Article
• Authors: Havula, Essi; Hietakangas, Ville
• Is Part Of: Current opinion in cell biology. Volume 51(2018)
• Page Start: 89
• Page End: 96
• Publication Date: 2018-04
• Subjects: Cells -- Periodicals; Cytology -- Periodicals; Cell Biology -- Periodicals; Biology -- Periodicals; Cells -- Periodicals; Review Literature -- Periodicals; Cell Biology; Biology; Cells; Review Literature; Cellules -- Périodiques; Cytologie -- Périodiques; Electronic journals; 571.6
• DOI: 10.1016/j.ceb.2017.12.007
• Languages: English
• ISSNs: 0955-0674

Abstract

Highlights: ChREBP/Mondo-Mlx is an intracellular sugar sensor conserved in animals. ChREBP/Mondo-Mlx integrates multiple nutrient-derived inputs. ChREBP/Mondo-Mlx controls the expression of hormones and transcription factors. Abstract : Animals regulate their physiology with respect to nutrient status, which requires nutrient sensing pathways. Simple carbohydrates, sugars, are sensed by the basic-helix–loop–helix leucine zipper transcription factors ChREBP/Mondo, together with their heterodimerization partner Mlx, which are well-established activators of sugar-induced lipogenesis. Loss of ChREBP/Mondo-Mlx in mouse and Drosophila leads to sugar intolerance, that is, inability to survive on sugar containing diet. Recent evidence has revealed that ChREBP/Mondo-Mlx responds to sugar and fatty acid-derived metabolites through several mechanisms and cross-connects with other nutrient sensing pathways. ChREBP/Mondo-Mlx controls several downstream transcription factors and hormones, which mediate not only readjustment of metabolic pathways, but also control feeding behavior, intestinal digestion, and circadian rhythm.