Bifurcation for a free boundary problem modeling tumor growth with ECM and MDE interactions. (October 2018)

• Record Type: Journal Article
• Authors: Pan, Hongjing; Xing, Ruixiang
• Is Part Of: Nonlinear analysis. Volume 43(2018)
• Page Start: 362
• Page End: 377
• Publication Date: 2018-10
• Subjects: Tumor growth -- Free boundary problem -- Symmetry-breaking bifurcation -- Spherical harmonics; Nonlinear functional analysis -- Periodicals; Analyse fonctionnelle non linéaire -- Périodiques; Nonlinear functional analysis; Periodicals; 515.7248
• DOI: 10.1016/j.nonrwa.2018.02.013
• Languages: English
• ISSNs: 1468-1218

Abstract

Abstract: We study a free boundary problem modeling solid tumor growth. The simplified model contains a parameter λ . Different from previous works on bifurcation analysis, a new ingredient of the present paper is that the influence of the extracellular matrix (ECM) and matrix degrading enzymes (MDE) interactions is included in the model. We first show that for each λ > 0, there exists a unique radially symmetric stationary solution with radius r = R S . Then we prove that there exist a positive integer n ∗ and a sequence of λ n ( n > n ∗ ) for which branches of symmetry-breaking stationary solutions bifurcate from the radially symmetric one. In particular, we discover that these λ n are larger than those λ ˜ n previously known when the effects of ECM and MDE are not considered in the model.