A clinical study and meta-analysis of carotid stenosis with coexistent intracranial aneurysms. (June 2018)

• Record Type: Journal Article
• Authors: Yang, Ximeng; Lu, Jun; Wang, Junjie; Wang, Lijun; Qi, Peng; Hu, Shen; Chen, Kunpeng; Wang, Daming
• Is Part Of: Journal of clinical neuroscience. Volume 52(2018)
• Page Start: 41
• Page End: 49
• Publication Date: 2018-06
• Subjects: Carotid stenosis -- Intracranial aneurysms -- Prevalence -- Meta-analysis; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2018.02.021
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: The prevalence of coexistent IAs in a large range of Chinese CS patients was reported for the first time. The first meta-analysis, including Western and Asian studies, to evaluate the prevalence of CS patients with coexistent IAs. Female CS patients have a higher risk to have coexistent IAs compared with male CS patients. Asian CS patients have a higher prevalence to have coexistent IAs than the European and American CS patients. Abstract: Carotid stenosis (CS) and intracranial aneurysms (IAs) may concur in one person. We studied the prevalence of IAs in CS patients in our retrospectively collected database and systematically reviewed this issue. Five hundred and fifty-seven CS (≥50%) patients confirmed by DSA in our hospital from 2010–06 to 2015–06 were screened for coexistent IAs. After searching the related literatures from English and Chinese journal literature databases, a meta-analysis was performed to pool the prevalence of CS with coexistent IAs. Subgroup analyses were performed to explore the causes of heterogeneity among studies. IAs were detected in 98(17.0%) out of the 577 CS patients. 12 literatures and the present study including a total of 6965 CS patients and 446 cases with coexistent IAs. The pooled prevalence of CS with coexistent IAs was 6.3% (95%CI: 4.2–8.3%) in all the CS patients. The pooled RR for female to male CS patients to have coexistent IAs was 1.67 (95%CI: 1.34–2.08, P = 0.000). 3 studies and the present study were carried out in Asian countries with a pooled prevalence of 10.8% (95%CI: 5.3–16.3%); 6 studies in European countries with 3.0% (95%CI: 2.2–3.7%); and 3 studies in USA with 6.0% (95%CI: 2.2–9.7%). There was a statistically significant difference between the three subgroups (P < 0.001). The prevalence of IAs in CS patients seems higher in our clinical study and the meta-analysis than in the general population and previously reported. The eastern and the women CS patients have a higher risk for coexistent IAs.