From nano to micro to macro: Electrospun hierarchically structured polymeric fibers for biomedical applications. (June 2018)

• Record Type: Journal Article
• Authors: Yang, Guang; Li, Xilin; He, Yang; Ma, Junkai; Ni, Guoli; Zhou, Shaobing
• Is Part Of: Progress in polymer science. Volume 81(2018)
• Page Start: 80
• Page End: 113
• Publication Date: 2018-06
• Subjects: 0-D zero dimensional -- 1-D one dimensional -- 2-D two dimensional -- 3-D three dimensional -- anti-EpCAM anti-epithelial cell adhesion molecule -- bFGF basic fibroblast growth factor -- BSHFs bead-on-string heterostructured fibers -- CFU Colony-Forming Units -- CTCs circulating tumor cells -- DC direct current -- DCM Dichloromethane -- DEPA delivery system on an electrospun pillar array -- DGNs dextran glassy nanoparticles -- DMAc Dimethylacetamide -- DMF N, N-Dimethylformamide -- DMNs dissolving microneedles -- DRG primary dorsal root ganglia -- ECs endothelial cells -- FDM fast-dissolving drug delivery membrane -- HFIP Hexafluoroisopropanol -- IBU ibuprofen -- MWCNTs multi-walled carbon nanotubes -- PAA poly(acrylic acid) -- PCL Poly(ε-caprolactone) -- PDMS poly (dimethylsiloxane) -- PE polyethylene -- PEG-PCL poly(ethylene glycol)-poly(ε-caprolactone) -- PEI poly(ether imide) -- PELA poly(ethylene glycol)-co-poly(d, l-lactide) -- PEO polyethylene oxide -- PGA poly(glycolic acid) -- PIPAAm poly(N −isopropylacrylamide) -- PLA poly(lactic acid) -- PLGA poly(lactic-co-glycolic acid) -- PLLA poly-l-lactic acid -- PS polystyrene -- PS-PSMA polystyrene-poly(styrene-co-maleic anhydride) -- PSNs polystyrene nanoparticles -- PU polyurethane -- PVA polyvinyl alcohol -- PVAc polyvinyl acetate -- PVD physical vapor deposition -- PVP polyvinyl pyrrolidone -- rBMSCs rat bone marrow mesenchymal stem cells -- TBT titanium butoxide -- TFE Trifluoroethanol -- THF Tetrahydrofuran -- WBC white blood cell; Hierarchical structures -- Biomaterials -- Drug delivery -- Tissue engineering -- Electrospinning -- Three-dimension; Polymers -- Periodicals; Polymerization -- Periodicals; Polymers -- Industrial applications -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.progpolymsci.2017.12.003
• Languages: English
• ISSNs: 0079-6700

Abstract

Abstract: Hierarchically structured polymer fibers encompassing 1-D, 2-D, and 3-D structures with at least one dimension nano- to micro-meters in size have recently received an increasing amount of attention due to their vast potential in such applications as sensing, medicine, energy storage. This review summarizes advancements in the last ten years in the design and fabrication of hierarchically structured polymer fibers via electrospinning technologies, including a diversity of electrospinning devices and electrospinning parameters using various polymers. These well-defined, multilevel structures enable the fibers to be used more effectively in applications in the biomedical field, such as drug delivery, tissue engineering, and diagnostics. This review can provide a better understanding of the relationships between the structure and functionality of polymer fibers for further biomedical applications.