Spontaneous brain tumor imaging of aged rat by crystal X-ray interferometer-based phase-contrast X-ray CT. (8th February 2016)

• Record Type: Journal Article
• Authors: Lwin, Thet-Thet; Yoneyama, Akio; Hara, Atsuko; Ohbu, Makoto; Maruyama, Hiroko; Taguchi, Masaya; Esashi, Shogo; Matsushima, Tsubasa; Terazaki, Kei; Hyodo, Kazuyuki; Takeda, Tohoru
• Is Part Of: Acta radiologica open. Volume 5:Number 2(2016)
• Publication Date: 2016-02-08
• Subjects: Crystal X-ray interferometer-based phase-contrast X-ray CT (C-PCCT) -- computed tomography (CT) -- aged rat -- spontaneous brain tumor; Radiology -- Periodicals; Diagnostic Imaging -- Periodicals; Radiology; Periodicals; 616.075705
• DOI: 10.1177/2058460115626958
• Languages: English
• ISSNs: 2058-4601

Abstract

Background: Crystal X-ray interferometer-based phase-contrast X-ray computed tomography (C-PCCT) enables the depiction of internal structures of biological tissue without contrast agents. Purpose: To determine the advantage of this technique in visualizing detailed morphological structures of a rare spontaneous brain tumor in an aged rat. Material and Methods: An aged rat's spontaneous brain tumor was imaged by C-PCCT without contrast agent. Three-dimensional (3D) images of the tumor microvasculature were reconstructed and compared with pathological pictures. Results: C-PCCT depicted the tumor's various pathological features clearly, e.g. its cell density and vasculature, and blood clots caused by hemorrhaging and/or hematomas. The obtained images resembled pathological pictures with a magnification of ×20 and were used to reconstruct 3D images of the tumor vascularity up to approximately 26 µm in diameter. Conclusion: Since C-PCCT is able to depict various pathological conditions, it might be useful for cancer research.