A Controlled, Randomized Clinical Study on the Impact of Treatment on Antral Mucociliary Clearance: Uncinectomy Versus Balloon Sinuplasty. (May 2016)

• Record Type: Journal Article
• Authors: Bizaki, Argyro J.; Numminen, Jura; Taulu, Rami; Rautiainen, Markus
• Is Part Of: Annals of otology, rhinology & laryngology. Volume 125:Number 5(2016:May)
• Page Start: 408
• Page End: 414
• Publication Date: 2016-05
• Subjects: endoscopic surgery -- endoscopic sinus surgery -- pansinusitis -- sinusitis -- Mucociliary clearance; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1177/0003489415618676
• Languages: English
• ISSNs: 0003-4894

Abstract

Objectives: To find out the effect of minimal invasive sinus surgery and balloon sinuplasty on mucociliary clearance and compare different methods of measuring mucociliary clearance. Methods: Twenty-nine patients with chronic rhinosinusitis were randomized in 2 operative groups (uncinectomy or balloon sinuplasty). Before and 6 months after the treatment, patients filled out a quality of life questionnaire (Sino Nasal Outcome Test-22 [SNOT-22]), and mucociliary clearance was measured with endoscope and gamma camera after 0.03 ml of saccharine, methylene-blue dye, and human albumin labeled with Tc99m was introduced to the bottom of maxillary sinuses. Results: In uncinectomy group, SNOT-22 score decreased, but treatment had no effect on mucociliary clearance. Based on saccharine test, smoking was associated with worse mucociliary clearance (r = 0.618, P < .05). Methylene blue test results associated with saccharine test (r = 0.434, P < .05) and Tc99m-labeled tracer technique (r = 0.261, P = .039) separately. Conclusion: Treatment positively affects patients' quality of life; however, it has no effect on mucociliary clearance. There was a statistically significant correlation between the Tc99m-labeled tracer technique and the methylene blue technique. The saccharine technique was even less accurate, but it can be useful in clinical practice because it is a quick, easy, and safe technique.