Assessment of pre‐operative maropitant citrate use in macaque (Macaca fasicularis & Macaca mulatta) neurosurgical procedures. Issue 3 (2nd April 2018)

• Record Type: Journal Article
• Authors: Steinbach, Jaclyn R.; MacGuire, Jamus; Chang, Shu; Dierks, Elizabeth; Roble, Gordon S.
• Is Part Of: Journal of medical primatology. Volume 47:Issue 3(2018)
• Page Start: 178
• Page End: 184
• Publication Date: 2018-04-02
• Subjects: cerenia -- maropitant citrate -- neurosurgery -- nonhuman primate -- post‐operative vomiting; Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12343
• Languages: English
• ISSNs: 0047-2565

Abstract

Abstract: Background: Retrospective analysis of post‐operative vomiting (POV) in non‐human primates at our institution was 11%. Based on this additional risk factor for post‐operative complications, we aimed to eliminate or decrease POV by adding an antiemetic, maropitant citrate, to the pre‐medication protocol. Methods: Retrospective and prospective data were collected over a 5‐year period from 46 macaques of two species during 155 procedures. Additionally, blood was collected from five Macaca mulatta to perform a pharmacokinetic analysis. Results: A 1 mg/kg subcutaneous dose of maropitant given pre‐operatively significantly decreased POV. Findings indicated post‐neurosurgical emesis in Macaca fasicularis was significantly greater than in Macaca mulatta . Pharmacokinetic analysis of maropitant in Macaca mulatta determined the mean maximum plasma concentration to be 113 ng/mL. Conclusions: Maropitant administration prior to anesthesia for neurosurgeries decreased our incidence of POV to 1%. The plasma concentration reaches the proposed plasma level for clinical efficacy approximately 20 minutes after administration.