Indium‐Mediated Domino Allylation‐Lactonisation Approach: Diastereoselective Synthesis of β‐Carboline C‐3 Tethered α‐Methylene γ‐Butyrolactones. Issue 17 (4th May 2018)

• Record Type: Journal Article
• Authors: Singh, Dharmender; Hazra, Chinmoy K.; Malakar, Chandi C.; Pandey, Satyendra K.; Kaith, B. S.; Singh, Virender
• Is Part Of: ChemistrySelect. Volume 3:Issue 17(2018)
• Page Start: 4859
• Page End: 4864
• Publication Date: 2018-05-04
• Subjects: Barbier-Type allylation -- α-Methylene γ-butyrolactone -- Molecular hybrid -- Natural product mimics -- Pictet-Spengler condensation; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201800006
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A facile and convenient tandem approach has been devised towards the diastereoselective synthesis of β‐carboline C‐3 tethered α‐methylene γ‐butyrolactones via indium‐promoted Barbier Type allylation reaction followed by in situ intramolecular lactonisation protocol. Interestingly, no additive was required for this transformation and the products were obtained with syn stereochemistry. Abstract : Hybridisation Approach: A one‐pot domino allylation‐lactonisation strategy has been formulated for the diastereoselective synthesis of novel β‐Carboline and α‐methylene γ‐butyrolactones based molecular hybrids.