Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci. (2nd January 2018)

• Record Type: Journal Article
• Authors: Rühlemann, Malte C.; Degenhardt, Frauke; Thingholm, Louise B.; Wang, Jun; Skiecevičienė, Jurgita; Rausch, Philipp; Hov, Johannes R.; Lieb, Wolfgang; Karlsen, Tom H.; Laudes, Matthias; Baines, John F.; Heinsen, Femke-Anouska; Franke, Andre
• Is Part Of: Gut microbes. Volume 9:Isuse 1(2018)
• Page Start: 68
• Page End: 75
• Publication Date: 2018-01-02
• Subjects: β diversity -- GWAS -- human gut microbiota -- immunity -- IBD; Gastrointestinal system -- Microbiology -- Periodicals; Microbiology -- Periodicals; Intestine, Small -- Periodicals; 616.3
• DOI: 10.1080/19490976.2017.1356979
• Languages: English
• ISSNs: 1949-0984

Abstract

ABSTRACT: Factors shaping the human intestinal microbiota range from environmental influences, like smoking and exercise, over dietary patterns and disease to the host's genetic variation. Recently, we could show in a microbiome genome-wide association study (mGWAS) targeting genetic variation influencing the β diversity of gut microbial communities, that approximately 10% of the overall gut microbiome variation can be explained by host genetics. Here, we report on the application of a new method for genotype-β-diversity association testing, the distance-based F (DBF) test. With this we identified 4 loci with genome-wide significant associations, harboring the genes CBEP4, SLC9A8, TNFSF4, and SP140, respectively. Our findings highlight the utility of the high-performance DBF test in β diversity GWAS and emphasize the important role of host genetics and immunity in shaping the human intestinal microbiota.