Effect of a novel polyethylene glycol compound on lung lavage in dogs after the inhalation of depleted uranium dust. (2nd April 2018)

• Record Type: Journal Article
• Authors: Ren, Jiong; Hao, Yuhui; Gao, Rui; Zhang, Ying; Ran, Yonghong; Liu, Jing; Dai, Xiaotian; Xiong, Wei; Su, Yongping; Li, Rong
• Is Part Of: International journal of radiation biology. Volume 94:Number 5(2018)
• Page Start: 462
• Page End: 471
• Publication Date: 2018-04-02
• Subjects: Depleted uranium -- inhalation -- bronchoalveolar lavage -- lung injury -- radioactive dust; Radiation -- Physiological effect -- Periodicals; Radiobiology -- Periodicals; 571.45
• DOI: 10.1080/09553002.2018.1446228
• Languages: English
• ISSNs: 0955-3002

Abstract

Abstract: Purpose: The purpose of this study was to assess the effect of a lavage solution containing methoxypolyethylene glycol 4-(3, 4-dihydroxyphenethylamino)-4-oxobutanoate (MDO) for whole lung lavage (WLL) in dogs after the inhalation of depleted uranium (DU) dust at a dose of 30 mgUkg −1 . Materials and methods: WLL was performed using lavage solutions made of normal saline (saline group) or normal saline plus MDO (MDO group) at 2 days post-DU exposure. Meanwhile, a control group was set up without any treatment. Results: At 10 days post-DU exposure, the saline and MDO groups had a lower DU content in urine and lung compared with the DU group (without lavage), while the MDO group content was significantly lower than that in the saline group. In terms of blood urea nitrogen and creatinine levels, the DU group maintained relatively high levels from day 3 to day 10; the saline group levels were reduced compared with the DU group at day 8 and day 10, while the MDO group levels remained markedly lower than both the DU and saline group levels. Pathological changes in the lungs and kidneys showed that the saline group was improved compared with the DU group, but not as significantly as the MDO group. Conclusions: In brief, WLL has a remarkable effect in promoting the decorporation of inhaled DU dust in the lungs of dogs. By comparison, a MDO-containing lavage solution has a better lavage effect than normal saline.