An overview of hypocretin based therapy in narcolepsy. (3rd April 2018)
- Record Type:
- Journal Article
- Title:
- An overview of hypocretin based therapy in narcolepsy. (3rd April 2018)
- Main Title:
- An overview of hypocretin based therapy in narcolepsy
- Authors:
- Takenoshita, Shinichi
Sakai, Noriaki
Chiba, Yuhei
Matsumura, Mari
Yamaguchi, Mai
Nishino, Seiji - Abstract:
- ABSTRACT: Introduction : Narcolepsy with cataplexy is most commonly caused by a loss of hypocretin/orexin peptide-producing neurons in the hypothalamus (i.e., Narcolepsy Type 1). Since hypocretin deficiency is assumed to be the main cause of narcoleptic symptoms, hypocretin replacement will be the most essential treatment for narcolepsy. Unfortunately, this option is still not available clinically. There are many potential approaches to replace hypocretin in the brain for narcolepsy such as intranasal administration of hypocretin peptides, developing small molecule hypocretin receptor agonists, hypocretin neuronal transplantation, transforming hypocretin stem cells into hypothalamic neurons, and hypocretin gene therapy. Together with these options, immunotherapy treatments to prevent hypocretin neuronal death should also be developed. Areas covered : In this review, we overview the pathophysiology of narcolepsy and the current and emerging treatments of narcolepsy especially focusing on hypocretin receptor based treatments. Expert opinion : Among hypocretin replacement strategies, developing non-peptide hypocretin receptor agonists is currently the most encouraging since systemic administration of a newly synthesized, selective hypocretin receptor 2 agonist (YNT-185) has been shown to ameliorate symptoms of narcolepsy in murine models. If this option is effective in humans, hypocretin cell transplants or gene therapy technology may become realistic in the future.
- Is Part Of:
- Expert opinion on investigational drugs. Volume 27:Number 4(2018)
- Journal:
- Expert opinion on investigational drugs
- Issue:
- Volume 27:Number 4(2018)
- Issue Display:
- Volume 27, Issue 4 (2018)
- Year:
- 2018
- Volume:
- 27
- Issue:
- 4
- Issue Sort Value:
- 2018-0027-0004-0000
- Page Start:
- 389
- Page End:
- 406
- Publication Date:
- 2018-04-03
- Subjects:
- Narcolepsy type1 -- narcolepsy type2 -- hypocretin -- orexin -- sleepiness -- cataplexy
Drugs -- Design -- Periodicals
Drugs, Investigational -- Bibliography
Drugs, Investigational -- Periodicals
615.1 - Journal URLs:
- http://informahealthcare.com/journal/eid ↗
http://www.ashley-pub.com/loi/eid ↗
http://informahealthcare.com ↗
http://puck.ashley-pub.com/vl=7681552/cl=12/nw=1/rpsv/journal/journal5_home.htm ↗ - DOI:
- 10.1080/13543784.2018.1459561 ↗
- Languages:
- English
- ISSNs:
- 1354-3784
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3842.002953
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 6466.xml