"Smart" Polymers: Physicochemical Characteristics and Applications in Bio-Separation Strategies. Issue 3 (3rd July 2018)

• Record Type: Journal Article
• Authors: Hernández-Vargas, Gustavo; Ponce-Ponce de León, César Alejandro; González-Valdez, José; Iqbal, Hafiz M. N.
• Is Part Of: Separation and purification reviews. Volume 47:Issue 3(2018)
• Page Start: 199
• Page End: 213
• Publication Date: 2018-07-03
• Subjects: Smart polymers -- bio-separation -- physiochemical features -- downstream bioprocessing; Separation (Technology) -- Periodicals; Chemicals -- Purification -- Periodicals; 660.2842
• DOI: 10.1080/15422119.2017.1356332
• Languages: English
• ISSNs: 1542-2119

Abstract

Abstract : In recent years, smart polymers (SPs), which are also referred to as bio-responsive polymers, have gained considerable attention as a unique class of polymers and their applications have been increasing significantly. These so-called "smart" polymers, either synthetic or biological, have been defined as "polymers designed to respond or undergo physical and structural conformational changes/rearrangement in response to slight changes in their surrounding environment". They are categorized as thermo-, pH-, electro- and magneto-responsive polymers. The advances in upstream bio-production stages and the high cost associated with downstream chromatographic techniques have pushed the development of new alternatives. In this context, the use of SPs, in combination with non-chromatographic technologies, represents a useful approach to the development of new downstream operation units. With the key scientific advancements, SPs have become the "next generation" of the bio-separation tool for eco-friendlier and cost-effective purification. This review describes the different characteristics and classifications of various "smart" polymers available for use in bio-separation strategy. Focus is also given to the recent advances in SP inclusion in the improvement of alternative non-chromatographic methods in downstream bioprocessings.