Delayed Metastasis of Clear Cell Sarcoma of Kidney to Bladder After 7 Disease-Free Years. (4th March 2018)

• Record Type: Journal Article
• Authors: Lang, Adam; Dehner, Louis P.
• Is Part Of: Fetal and pediatric pathology. Volume 37:Number 2(2018)
• Page Start: 126
• Page End: 133
• Publication Date: 2018-03-04
• Subjects: Clear cell sarcoma of kidney -- bladder -- delayed metastasis -- Cyclin D1 -- inflammatory myofibroblastic tumor -- rhabdomyosarcoma; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2018.1435757
• Languages: English
• ISSNs: 1551-3815

Abstract

ABSTRACT: Introduction : Clear cell sarcoma of the kidney (CCSK) is childhood neoplasm with its own distinctive pattern of metastasis and may appear after a disease free interval of 5 years or more. Materials and Methods : Histopathology and immunohistochemistry were available from the radical nephrectomy and the later partial cystectomy, which was performed after a seven disease-free interval. Results : The pathologic features of the primary tumor were those of a classic CCSK with a monotypic pattern of uniform rounded to ovoid tumor cells with a background network of delicate blood vessels. By contrast, the bladder recurrence had a myxoid hypocellular appearance (one of the known variant patterns of CCSK). Both tumors displayed immunopositivity for Cyclin-D1 and CD117 with a less intense reaction in the bladder metastasis. Conclusions : This case demonstrates that CCSK has the potential to metastasize after a prolonged disease-free interval and may have deceptively bland histopathologic features.