Molecular markers in disease detection and follow-up of patients with non-muscle invasive bladder cancer. (4th May 2018)

• Record Type: Journal Article
• Authors: Maas, Moritz; Walz, Simon; Stühler, Viktoria; Aufderklamm, Stefan; Rausch, Steffen; Bedke, Jens; Stenzl, Arnulf; Todenhöfer, Tilman
• Is Part Of: Expert review of molecular diagnostics. Volume 18:Number 5(2018)
• Page Start: 443
• Page End: 455
• Publication Date: 2018-05-04
• Subjects: Molecular urine markers -- non-muscle invasive bladder cancer -- disease detection -- follow-up -- cell-free DNA; Molecular diagnosis -- Periodicals; 616.0758205
• DOI: 10.1080/14737159.2018.1469979
• Languages: English
• ISSNs: 1473-7159

Abstract

ABSTRACT: Introduction : Diagnosis and surveillance of non-muscle invasive bladder cancer (NMIBC) is mainly based on endoscopic bladder evaluation and urine cytology. Several assays for determining additional molecular markers (urine-, tissue- or blood-based) have been developed in recent years but have not been included in clinical guidelines so far. Areas covered : This review gives an update on different molecular markers in the urine and evaluates their role in patients with NMIBC in disease detection and surveillance. Moreover, the potential of recent approaches such as DNA methylation assays, multi-panel RNA gene expression assays and cell-free DNA analysis is assessed. Expert commentary : Most studies on various molecular urine markers have mainly focused on a potential replacement of cystoscopy. New developments in high throughput technologies and urine markers may offer further advantages as they may represent a non-invasive approach for molecular characterization of the disease. This opens new options for individualized surveillance strategies and may help to choose the best therapeutic option. The implementation of these technologies in well-designed clinical trials is essential to further promote the use of urine diagnostics in the management of patients with NMIBC.