Karyoptosis: A novel type of cell death caused by chronic autophagy inhibition. Issue 4 (3rd April 2018)

• Record Type: Journal Article
• Authors: Baron, Olga; Fanto, Manolis
• Is Part Of: Autophagy. Volume 14:Issue 4(2018)
• Page Start: 722
• Page End: 723
• Publication Date: 2018-04-03
• Subjects: Atrophin -- autophagy -- cell death -- EPG5 -- neurodegeneration -- nucleophagy -- polyglutamine; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2018.1434372
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: Macroautophagy/autophagy influences onset and progression of several human neurodegenerative diseases, because of its critical role as a regulator of neuronal proteostasis and organelle quality control. In many neurodegenerative diseases, impairment in autophagy is thought to play a fundamental part in the terminal phases of cellular degeneration and death. However, the ultimate mechanism of neuronal cell death remains elusive. In a recent study we have identified a new form of regulated cell death, which arises upon autophagy inhibition.