The small GTPase RAB37 functions as an organizer for autophagosome biogenesis. Issue 4 (3rd April 2018)

• Record Type: Journal Article
• Authors: Song, Ying; Shang, Dantong; Cheng, Hanhua; Zhou, Rongjia
• Is Part Of: Autophagy. Volume 14:Issue 4(2018)
• Page Start: 727
• Page End: 729
• Publication Date: 2018-04-03
• Subjects: autophagosome -- autophagy -- cell homeostasis -- GTPase -- membrane -- RAB proteins; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2018.1434374
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: Macroautophagy/autophagy is a catabolic process that is essential for cellular homeostasis. How autophagosomal vesicle forms in a spatio-temporally regulated manner remains elusive. Our recent study revealed that small GTPase, RAB37 (RAB37, member RAS oncogene family), functions as a key organizer of autophagosomal membrane biogenesis. RAB37 interacts with ATG5 (autophagy related 5) and promotes autophagosome formation by modulating ATG12–ATG5-ATG16L1 complex assembly. These findings provide new insights into autophagy regulation.