Cover Feature: Macromolecular Crowding May Significantly Affect the Performance of an MRI Contrast Agent: A 1H NMR Spectroscopy, Microimaging, and Fast‐Field‐Cycling NMR Relaxometry Study (ChemistryOpen 4/2018). Issue 4 (25th March 2018)

• Record Type: Journal Article
• Authors: Cheng, Ren‐Hao; Chen, Jie‐Min; Chen, Yu‐Wen; Cai, Honghao; Cui, Xiaohong; Hwang, Dennis W.; Chen, Zhong; Ding, Shangwu
• Is Part Of: ChemistryOpen. Volume 7:Issue 4(2018)
• Page Start: 276
• Page End: 276
• Publication Date: 2018-03-25
• Subjects: imaging agents -- macromolecular crowding effect -- magnetic resonance imaging -- NMR spectroscopy -- relaxivity; Chemistry -- Periodicals; 540; 540.5
• DOI: 10.1002/open.201800033
• Languages: English
• ISSNs: 2191-1363

Abstract

Abstract : The Cover Feature shows that macromolecular crowders PEG or BSA in an aqueous solution of a paramagnetic magnetic resonance imaging (MRI) contrast agent generally bring additional proton spin relaxation to the water molecules close to the paramagnetic ion and lead to contrast change in the MRI images. This highlights the importance of considering the effect of macromolecular crowding on the performance of MRI contrast agents and image analysis, as well as diagnosis in clinical and functional MRI. More information can be found in the Full Paper onpage 288 in Issue 4, 2018 by R.‐H. Cheng et al. (DOI:10.1002/open.201700192 ).