Continuous Glucose Monitoring in Pregnant Women With Type 1 Diabetes (CONCEPTT): A Multicenter International Randomised Controlled Trial. Issue 4 (April 2018)

• Record Type: Journal Article
• Authors: Feig, Denice S.; Donovan, Lois E.; Corcoy, Rosa; Murphy, Kellie E.; Amiel, Stephanie A.; Hunt, Katharine F.; Asztalos, Elizabeth; Barrett, Jon F. R.; Sanchez, J. Johanna; de Leiva, Alberto; Hod, Moshe; Jovanovic, Lois; Keely, Erin; McManus, Ruth; Hutton, Eileen K.; Meek, Claire L.; Stewart, Zoe A.; Wysocki, Tim; O'Brien, Robert; Ruedy, Katrina; Kollman, Craig; Tomlinson, George; Murphy, Helen R.
• Is Part Of: Obstetrical & gynecological survey. Volume 73:Issue 4(2018)
• Publication Date: 2018-04
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Surgery -- Periodicals; 618
• DOI: 10.1097/01.ogx.0000532199.80944.24
• Languages: English
• ISSNs: 0029-7828

Abstract

Abstract : (Abstracted from Lancet 2017;390:2347–2359) It is established that optimal maternal glycemic control throughout pregnancy is associated with a decrease in adverse fetal outcomes. A proper glycemic index can be difficult to control in women with type 1 diabetes during pregnancy because of the complexity of insulin dose adjustment, gestational changes in insulin sensitivity, and day-to-day changes to insulin absorption in late pregnancy. Nationwide UK data show the rates of severe hypoglycemia, particularly in early pregnancy, are 5 times higher among pregnant women than nonpregnant and that only 40% of women with type 1 diabetes achieve target glycated hemoglobin (HbA1c ) after 24 weeks of gestation. Continuous glucose monitoring (CGM) provides real-time quantitative information on the direction and rate of change of glucose levels.