50. PINEAL MIXED GERM CELL TUMOUR: A CASE REPORT AND LITERATURE RIVIEW. (February 2015)

• Record Type: Journal Article
• Authors: Ahadi, Mahsa S.; Soh, Hwei Choo; Brewer, Janice
• Is Part Of: Pathology. Volume 47(2015)Supplement 1
• Publication Date: 2015-02
• Subjects: Pathology -- Periodicals; 616.0705
• DOI: 10.1097/01.PAT.0000461659.86222.07
• Languages: English
• ISSNs: 0031-3025

Abstract

Abstract : Introduction: Primary germ cell tumour in the pineal region is very rare among all primary intracranial neoplasms, accounting for approximately 2% of these tumours. Mixed germ cell tumours are one of the six histologic subtypes which account for 10–13% of pineal germ cell tumours. Case report: We present a case of mixed germ cell tumour in an 18-year-old male. He presented with a long history of confusion, memory loss, occasional headaches and diabetes insipidus. Neurological examination revealed Parinaud's syndrome. The MRI scan demonstrated a complex pineal region lesion with a large component of fat. Histologically, the tumour was shown to be a mixed germ cell tumour with germinoma accounting for greater than 95% and mature teratoma for less than 5% of the biopsies. Discussion: In summary, a rare case of pineal mixed germ cell tumour is presented and the literature is reviewed.