Vitamin D Status Affects Serum Metabolomic Profiles in Pregnant Adolescents. (June 2015)

• Record Type: Journal Article
• Authors: Finkelstein, Julia L.; Pressman, Eva K.; Cooper, Elizabeth M.; Kent, Tera R.; Bar, Haim Y.; O'Brien, Kimberly O.
• Is Part Of: Reproductive sciences. Volume 22:Number 6(2015:Jun.)
• Page Start: 685
• Page End: 695
• Publication Date: 2015-06
• Subjects: adolescent -- pregnancy -- vitamin D -- biomarker -- metabolomics; Reproductive health -- Periodicals; Reproduction -- Periodicals; 612.6
• DOI: 10.1177/1933719114556477
• Languages: English
• ISSNs: 1933-7191

Abstract

Vitamin D is linked to a number of adverse pregnancy outcomes through largely unknown mechanisms. This study was conducted to examine the role of vitamin D status in metabolomic profiles in a group of 30 pregnant, African American adolescents (17.1 ± 1.1 years) at midgestation (26.8 ± 2.8 weeks), in 15 adolescents with 25-hydroxy vitamin D (25(OH)D) ≥20 ng/mL, and in 15 teens with 25(OH)D <20 ng/mL. Serum metabolomic profiles were examined using gas chromatography–mass spectrometry and liquid chromatography–tandem mass spectrometry. A novel hierarchical mixture model was used to evaluate differences in metabolite profiles between low and high groups. A total of 326 compounds were identified and included in subsequent statistical analyses. Eleven metabolites had significantly different means between the 2 vitamin D groups, after correcting for multiple hypothesis testing: pyridoxate, bilirubin, xylose, and cholate were higher, and leukotrienes, 1, 2-propanediol, azelate, undecanedioate, sebacate, inflammation associated complement component 3 peptide (HWESASXX), and piperine were lower in serum from adolescents with 25(OH)D ≥20 ng/mL. Lower maternal vitamin D status at midgestation impacted serum metabolic profiles in pregnant adolescents.