Acute graft-versus-host disease, invasive aspergillosis and Clostridium difficile colitis after peripheral blood stem cell transplantation: A complex network of causalities and a challenge for prevention. (June 2015)

• Record Type: Journal Article
• Authors: Khanafer, Nagham; Neuraz, Antoine; Bénet, Thomas; Cour, Martin; Persat, Florence; Labussière, Hélène; Argaud, Laurent; Michallet, Mauricette; Vanhems, Philippe
• Is Part Of: Anaerobe. Volume 33(2015)
• Page Start: 98
• Page End: 100
• Publication Date: 2015-06
• Subjects: Bone marrow transplant -- Clostridium difficile infection -- Invasive aspergillosis -- Graft-versus-host disease -- Nosocomial -- Environmental transmission; Anaerobic infections -- Periodicals; Anaerobic bacteria -- Periodicals; Bacterial diseases -- Periodicals; Computer network resources; Anaerobic protozoa -- Periodicals; 579.3
• DOI: 10.1016/j.anaerobe.2015.02.007
• Languages: English
• ISSNs: 1075-9964

Abstract

Abstract: Graft-versus-host disease (GVHD) is a known risk factor for invasive aspergillosis (IA), but remains poorly studied in relation to Clostridium difficile infection (CDI). We report a case of a 58-years-old patient who developed an IA within a protected room, CDI and GVHD after allogeneic allogeneic peripheral blood stem cell transplantation (PBSCT). Factors associated with this complex condition in patients receiving allogeneic PBSCT need to be identified. Highlights: We describe a complex life-threatening condition after allogeneic PBSCT. GVHD may increase the risk of CDI and CDI may increase the risk of GVHD. Importance of surface monitoring in hematopoietic units. Need to identify factors associated with GVHD, CDI and IA after allogeneic PBSCT.