A comparative study of event-related coupling patterns during an auditory oddball task in schizophrenia. (4th December 2014)

• Record Type: Journal Article
• Authors: Bachiller, Alejandro; Poza, Jesús; Gómez, Carlos; Molina, Vicente; Suazo, Vanessa; Hornero, Roberto
• Is Part Of: Journal of neural engineering. Volume 12:Number 1(2015:Feb.)
• Publication Date: 2014-12-04
• Subjects: neuroscience -- EEG and MEG -- synchronization in the nervous system -- neural networks -- biological signal processing; Neurosciences -- Periodicals; Biomedical engineering -- Periodicals; 612.8
• DOI: 10.1088/1741-2560/12/1/016007
• Languages: English
• ISSNs: 1741-2560

Abstract

Abstract: Objective. The aim of this research is to explore the coupling patterns of brain dynamics during an auditory oddball task in schizophrenia (SCH). Approach. Event-related electroencephalographic (ERP) activity was recorded from 20 SCH patients and 20 healthy controls. The coupling changes between auditory response and pre-stimulus baseline were calculated in conventional EEG frequency bands (theta, alpha, beta-1, beta-2 and gamma), using three coupling measures: coherence, phase-locking value and Euclidean distance. Main results. Our results showed a statistically significant increase from baseline to response in theta coupling and a statistically significant decrease in beta-2 coupling in controls. No statistically significant changes were observed in SCH patients. Significance. Our findings support the aberrant salience hypothesis, since SCH patients failed to change their coupling dynamics between stimulus response and baseline when performing an auditory cognitive task. This result may reflect an impaired communication among neural areas, which may be related to abnormal cognitive functions.